S01 Development of sleep in the first year of life

S01 Development of sleep in the first year of life
Saturday, April 28 | 9:40am-11:10am | Room Bordeaux

Chair: Patricia Franco (France)

9:40am – 9:42am
Patricia Franco (France)

9:42am – 9:58am
Using oximetry to measure intermittent hypoxia in preterm and term infants
Dawn Elder (New Zealand)

9:58am – 10:14am
Body temperatures before and after sleep onset in preterm neonates
Veronique Bach (France)

10:14am – 10:30
Longitudinal effects of apnoea and periodic breathing on cerebral oxygenation – a risk for neurodevelopmental impairment?
Rosemary Horne (Australia)

10:30am – 10:46am
Sleep quality of 8-12 months old infants using Actigraphy and sleep diaries
Frank Wiesemann (Germany)

10:46am – 11:02am
Early polysomnographic characteristics associated with neurocognitive development at 3 years of age
Patricia Franco (France)

11:02am – 11:10am
Question and Answer
Patricia Franco (France)

Summary of symposium:
Sleep is essential for normal development and is particularly important in infancy and early childhood as infants spend over 70% of each 24 hours asleep and children around 50%. Sleep states have a significant effect on the cardiovascular system and temperature regulation. As these systems are immature in the first years of life, particularly in infants born preterm, instabilities in cardiorespiratory and temperature control are common. These can have significant long term consequences for infant development. This symposium will discuss the effects of respiratory instability and control of temperature during the newborn and postnatal period and the longer term consequences of any disruptions.

Prof Bach will report of her study of body (distal and proximal) temperature evolution according to time before sleep onset in preterm neonates. Her results point out distal vasodilation and distal to proximal gradient increase before sleep onset as it has already been observed in adults and elderly people.

Prof Elder will present data on intermittent hypoxia measured in preterm and term infants through the first year of life by assessing the desaturation index (DSI) on overnight oximetry. The presentation will discuss differences between DSI values in term and preterm infants, changes over the first year of life and whether it is possible to predict at neonatal discharge infants who will have ongoing respiratory instability after discharge home.

Prof Horne will present data contrasting the consequences of apnoea and periodic breathing in term and preterm infants on cerebral oxygenation over the first 6 months after term equivalent age. These studies highlight the significant effects of short apnoeas, which are normally thought benign, on the developing brain.

Dr Wiesemann will present results of a large base sleep study (100 infants, 8-12 m of age) in a home setting. Sleep was measured with an Accelerometer (Actigraph wGT3X-BT) and sleep diaries. Insights for normal sleep patterns of babies at this age will be reported. Different analysis approaches to analyse Accelerometer data for sleep quality will also be presented.

Prof Franco will present data from the French birth-cohort AuBE study which assessed sleep and neurodevelopment at birth, 6 months and 3 years of age. Full-scale and particularly verbal IQ scores at 3 years old could be impacted by early sleep characteristics measured by PSG. Daytime active sleep percentage may favour verbal capacity while number of arousals per hour during night-sleep may be detrimental to it when adjusted on night or day characteristics and maternal and child risk factors.

Learning Objectives:
Upon completion of this CME activity, participants should be able to understand
1. The importance of sleep during infancy.
2. The importance of temperature regulation in the preterm neonate.
3. The consequences of respiratory instability during sleep during the first year of life.
4. The implications of disruption of sleep and sleep patterns infants and the implications for development and learning.

Target Audience:
Clinicians, sleep researchers