MILD MATERNAL OBSTRUCTIVE SLEEP APNEA IN NON-OBESE PREGNANT WOMEN AND ACCELERATED FETAL GROWTH

Oral Session 2
Saturday, April 28, 2018 | 4:00pm-5:30pm | Room 342B

5:15pm-5:30pm
MILD MATERNAL OBSTRUCTIVE SLEEP APNEA IN NON-OBESE PREGNANT WOMEN AND ACCELERATED FETAL GROWTH

Authors:
Riva Tauman (Israel)*
Ayana Telerant (Israel)
Galit Levi Dunietz (Israel)
Ariel Many (Israel)

Introduction

Snoring is common during pregnancy and affects up to one-third of women by the third trimester. The prevalence of OSA during pregnancy is rising. OSA during pregnancy has been associated with adverse maternal outcomes. The effect of maternal OSA on the fetus, particularly on fetal growth, is less apparent.  Our objective was to evaluate the association between maternal obstructive sleep apnea (OSA) and fetal growth in non-obese women with uncomplicated pregnancies.

Materials and methods

Pregnant women were recruited prospectively during their third trimester. All participants completed questionnaires on general health and pregnancy characteristics, the Berlin and the Epworth sleepiness scales, and underwent an ambulatory sleep assessment between 33 to 36 weeks of gestation. We also conducted a medical chart review for delivery and newborn characteristics.

Results

A total of 155 non-obese pregnant women were recruited, and 26 (17%) of them had mild OSA. None of the participants developed pregnancy complications. The mean birthweight percentile of the newborns of women with mild OSA (apnea hypopnea index 5-15/h) was significantly higher compared with the newborns of the 129 non-OSA controls (72% vs. 57%, respectively, P < 0.01). The proportion of large for gestational age (LGA) newborns was significantly higher among women with OSA compared with controls (28% vs. 8%, respectively, P = 0.04), and the proportion of Apgar scores <7 at 1 minute was also significantly higher (23% vs. 5%, respectively, P < 0.01). Bivariate and multivariate logistic regression analyses showed that women with mild OSA had increased odds for LGA newborns compared with controls (OR=5.1, 95% CI 1.3, 20.0).

Conclusions

Our results suggest that maternal OSA during the third trimester of pregnancy — even in a mild form — is associated with accelerated fetal growth.

Acknowledgements

This research was supported by the Israel Science Foundation (grant No. 707/12)