LONGITUDINAL STUDY OF OBSTRUCTIVE SLEEP APNOEA IN CHILDHOOD, ADOLESCENCE AND YOUNG ADULTHOOD

Oral Session 3
Sunday, April 29, 2018 | 10:40am-12:10pm | Room 342B

11:10am-11:25am
LONGITUDINAL STUDY OF OBSTRUCTIVE SLEEP APNOEA IN CHILDHOOD, ADOLESCENCE AND YOUNG ADULTHOOD

Authors:
Chun Ting Au (Hong Kong)*
Kate Ching Ching Chan (Hong Kong)
Albert Martin Li (Hong Kong)

Introduction

It is believed that obstructive sleep apnoea (OSA) in children is different from that in adults. However, longitudinal data tracking the disease from childhood to adulthood is lacking. This study aimed to examine the natural history of obstructive sleep apnoea (OSA) from childhood to early adulthood.

Materials and methods

This was a prospective longitudinal study with 3 visits across 10 years. The cohort was established in year 2003-2005 for the investigation of the epidemiology of childhood OSA, in which children aged between 6 and 13 years old were recruited. Two follow-up visits were then conducted at 5-year intervals, at their adolescence and early adulthood, respectively. OSA was defined as having an obstructive apnoea hypopnoea index (OAHI) of >=1/h at childhood and adolescence, and an OAHI of >=5/h at young adulthood.

Results

A total of 122 subjects completed all the 3 visits, of whom 50 had OSA at baseline. Among the 50 subjects with OSA at their childhood, 15 (30%) of them remained to have OSA at both adolescence and early adulthood, 1 (2%) of them had OSA resolved at adolescence but relapsed at early adulthood, and the remaining 34 (68%) subjects had OSA resolved spontaneously. Among the 72 subjects without OSA at their childhood, 27 (38%) of them had incident OSA at adolescence, of whom 12 remained to have OSA at their adulthood while 15 resolved. Another 4 (6%) of them had
incident OSA at early adulthood. The remaining 41 subjects had no OSA throughout 3 visits. At early adulthood, 32 subjects were found to have OSA, of whom only 4 (13%) were adult-onset while the others had been previously diagnosed at their childhood and/or adolescence. Logistic regression analysis revealed that adulthood OSA was associated with the presence of OSA in adolescence [OR(95%CI)=8.2(2.3-29.4), p=0.001] but not OSA in childhood (p=0.7).

Conclusions

Majority of OSA at childhood resolved spontaneously during growth. On the other hand, OSA in early adulthood of most cases were initiated at younger ages, especially during adolescence.

Acknowledgements

This study was funded by the Research Grants Council of the Hong Kong Special Administrative Region, China [CUHK470913]